Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication
Identifieur interne : 002768 ( Main/Exploration ); précédent : 002767; suivant : 002769Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication
Auteurs : Roger Deloncle [France] ; Olivier Guillard [France]Source :
- Neurochemical Research [ 0364-3190 ] ; 1990-12-01.
Abstract
Abstract: The authors are convinced that in Alzheimer's disease, as in Down's syndrome and Guam-Parkinson dementia, one may find an alteration in blood brain barrier transfer and a resultant imbalance in mineral metabolism. Metals, such as aluminium, which in vivo yield stable complexes with aspartic and glutamic acids act as previously been clearly shown with glutamic acid; they cross the blood brain barrier, and are deposited in the brain. The authors explain how amyloid protein or neurofibrillary tangles could well be produced by aluminium complex formation. Whithin the brain, in the form precisely of aluminium complex,l-glutamic acid is consequently unable to detoxify ammonia from neurons and to produce L-glutamin. Accumulation of ammonia is subsequently responsible for the neuronal death, affecting each and every neurotransmitter system.
Url:
DOI: 10.1007/BF01208586
Affiliations:
- France
- Aquitaine-Limousin-Poitou-Charentes, Centre-Val de Loire, Poitou-Charentes, Région Centre
- Poitiers, Tours
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